You have found a mutant phenotype in your lab mice that is associated with reduced metabolic rate. You are interested in determining the genetic basis for this phenotype. You have generated inbred (Դrue-breedingԩ lines with both ԮormalԠand ԬowԠmetabolic rates. For each of the following crosses predict what percentage of both male and female offspring will have the low metabolic rate phenotype assuming the gene is autosomal. Then repeat your predictions under the assumption that gene is X-linked. Finally repeat your predictions under the assumption that the gene is mitochondrial. You can assume the following for this question: 1) a single gene is responsible for the change in phenotype and 2) the allele for low metabolic rate is recessive (where applicable). [You do not need to explain your answers for this question].a. Inbred ԬowԠfemale x inbred ԮormalԠmaleb. Inbred ԮormalԠfemale x inbred ԬowԠmalec. F1 female from cross (a) x F1 male from cross (a) d. F1 female from cross (b) x F1 male from cross (b)Fill out this table with the predicted percentages of offspring with the ԬowԠphenotype.AutosomalX-linkedMitochondrialMale OffspringFemale OffspringMale OffspringFemale OffspringMale OffspringFemale Offspringabcd2. Based on your answers to question #1 which cross would you recommend as the most efficient way to determine the location of the gene in question? [Note that there are multiple reasonable answers to this question. What is most important is that you clearlyexplain the logic for why you chose the cross that you did.]
